A candidate variant study to followup, in an independent cohort of 20,138 MS cases and controls, 5 variants that achieved strong support in IMSGC and WTCCC2 studies but failed to reach genome-wide significance. Genotyping was performed using TaqMan, MassARRAY iPlex or Human610-Quad Illumina array resulting after QC in genotype for 8,499 MS cases, 8,765 controls and 958 trios. An association analysis was performed using PLINK. P-Values from the original WTCCC2 and IMSGC studies were combined with those for this study using METAL. All 5 candidate variants reached genome-wide significance in this meta-analysis.