Overview

A combined analysis for inflammatory bowel disease (IBD) GWA scan of 12,924 cases and 35,391 controls for Crohn's disease (CD) or ulcerative colitis (UC) was carried out using HapMap phase 3 (CEU+TSI) data to impute 1.23M SNPs. Imputation was carried out using Beagle 3.1 and association was calculated using PLINK. A meta-analysis was perfomed by combining the above, filtered by P.association < 0.01, with a replication cohort of 25,683 disease cases and 15,977 controls genotyped on the ImmunoChip platform. This identified 23 (12 novel) UC loci, 30 (16 novel) CD loci and 64 (8 novel) IBD loci.

Study Type
Case-Control Study
Samples
GroupPhenotypePopulationCasesControlsFamiliesTrios
DiscoveryCRO595614927--
DiscoveryUC696820464--
ReplicationCRO14763---
ReplicationIBD-15977--
ReplicationUC10920---
Exclusion Criteria

Discovery

In addition to previously reported cohort QC, samples were excluded due to...

  • Call rate <98%
  • Heterozygosity ±0.2

Markers were excluded due to...

  • HWE (controls) P<10-6
  • HWE (cases) P<10-10
  • Call rate <95%
  • Difference in call rate between cases and controls > 2%

Replication

Samples

  • Call rate <95%
  • Heterozygosity outside CI 95% per batch
  • Non-European ancestry
  • Abnormal mean-intensity values
  • Duplicate and closely-related samples

Markers

  • Call rate <98%
  • HWE P<10-10
  • Manual QC for those SNPs with meta-analysis P<10-5

Study Association

RegionLocationGene(s)MarkerAlleleMAFP ValueOdds Ratio
1p12chr1:119807450-120084479ADAM30  rs3897478T > C0.1092.78e-07C1.11 (1.06-1.16)C
1p13.2chr1:113288123-114002809DCLRE1B  PTPN22  rs6679677C > A0.0933.15e-03C1.06 (1.01-1.11)C
1p31.1chr1:77522888-78355813rs17391694C > T0.1114.93e-06C1.09 (1.04-1.14)C
1p31.1chr1:70524556-70651887rs2651244G > A0.4014.81e-01C1.01 (0.99-1.04)C
1p31.3chr1:67128876-67302310IL23R  IL12RB2  rs11209026G > A0.0678.12e-161C2.0 (1.89-2.13)C
1p36.12chr1:22326008-22411939rs12568930T > C0.1797.42e-14C1.1 (1.05-1.14)C
1p36.13chr1:19821756-19953230rs6426833A > G0.4582.02e-28C1.11 (1.09-1.15)C
1p36.23chr1:7853370-8140630TNFRSF9  rs35675666G > T0.1621.12e-15C1.11 (1.06-1.15)C
1p36.32chr1:2431888-2879054TNFRSF14  MMEL1  PLCH2  rs10797432C > T0.4784.65e-07C1.03 (1.01-1.06)C
1p36.33chr1:1190173-1452909TNFRSF18  TNFRSF4  rs12103G > A0.1827.66e-13C1.10 (1.06-1.14)C
1q21.3chr1:151565936-152018664RORC  rs4845604G > A0.1435.32e-16C1.15 (1.1-1.19)C
1q22chr1:155052885-156118465RIT1  UBQLN4  MSTO1  rs670523G > A0.3243.67e-07C1.06 (1.03-1.09)C
1q23.3chr1:161419627-161668253HSPA6  FCRLA  FCGR3A  FCGR3B  FCGR2B  FCGR2A  rs1801274A > G0.4913.52e-28C1.12 (1.09-1.16)C
1q23.3chr1:160727284-160979324CD48  CD244  ARHGAP30  USF1  ITLN1  F11R  SLAMF7  SLAMF1  rs4656958G > A0.3146.80e-09C1.06 (1.03-1.1)C
1q24.3chr1:172711325-172972573FASLG  TNFSF18  rs9286879A > G0.2491.92e-07C1.07 (1.03-1.10)C
1q31.3chr1:197342098-197969200C1orf53  rs2488389G > A0.2205.22e-12C1.12 (1.08-1.15)C
1q32.1chr1:206709013-206867232FCMR  IL19  MAPKAPK2  IL10  PIGR  IL20  IL24  RASSF5  rs3024505G > A0.1606.66e-42C1.21 (1.16-1.25)C
1q32.1chr1:200062588-200168521rs2816958G > A0.1138.22e-10C1.12 (1.08-1.18)C
1q32.1chr1:200892467-201069559KIF21B  rs7554511C > A0.2751.24e-32C1.16 (1.12-1.2)C
2p14chr2:65250869-65490608SPRED2  rs6740462A > C0.2612.35e-08C1.08 (1.04-1.11)C
2p15chr2:62256286-62420888rs10865331G > A0.3962.26e-02C1.05 (1.02-1.08)C
2p16.1chr2:60706158-61642429KIAA1841  AHSA2  C2orf74  REL  rs7608910A > G0.3948.65e-32C1.14 (1.11-1.17)C
2p21chr2:43221519-43708586rs10495903C > T0.1303.20e-10C1.09 (1.04-1.13)C
2p23.2chr2:28377859-28449611FOSL2  BRE  rs925255C > T0.4432.49e-14C1.09 (1.06-1.12)C
2p23.3chr2:24464482-25234839ADCY3  rs6545800C > T0.4459.40e-15C1.11 (1.08-1.14)C
2p23.3chr2:27154127-28142797UCN  rs1728918G > A0.2998.44e-09C1.07 (1.04-1.10)C
2q12.1chr2:102238781-102651983IL18RAP  IL1RL1  IL1R2  IL18R1  IL1R1  IL1RL2  rs917997C > T0.2316.17e-17C1.10 (1.07-1.14)C
2q24.2chr2:162104363-162502867IFIH1  rs2111485G > A0.4042.52e-07C1.07 (1.04-1.10)C
2q32.3chr2:190986040-191143008STAT4  STAT1  rs1517352C > A0.4003.28e-11C1.08 (1.04-1.11)C
2q33.1chr2:197277486-198096744PLCL1  RFTN2  rs1016883G > A0.1833.61e-03C1.04 (1.0-1.08)C
2q33.1chr2:198492027-198792296rs17229285T > C0.4963.76e-06C1.06 (1.03-1.09)C
2q35chr2:218074907-218395928TMBIM1  CTDSP1  CXCR2  ARPC2  SLC11A1  PNKD  CXCR1  rs2382817C > A0.4083.70e-12C1.07 (1.04-1.10)C
2q37.1chr2:230181042-230371171SP140  rs6716753T > C0.1961.52e-09C1.09 (1.05-1.13)C
2q37.1chr2:233232538-233674416INPP5D  ATG16L1  rs12994997A > G0.4775.04e-35C1.14 (1.1-1.16)C
2q37.3chr2:240619922-240712978GPR35  rs3749171C > T0.1672.24e-20C1.14 (1.09-1.18)C
3p21.1chr3:52314348-53145738ITIH4  PRKCD  rs9847710T > C0.4163.14e-03C1.04 (1.01-1.07)C
3p21.31chr3:48465783-50711580PFKFB4  IP6K1  USP4  UCN2  GPX1  MST1  MST1R  IP6K2  BSN  rs3197999G > A0.2961.01e-47C1.18 (1.14-1.22)C
3p24.3chr3:18566300-18808423rs4256159C > T0.1401.65e-11C1.11 (1.06-1.15)C
4p11chr4:48158462-52069158TXK  SLC10A4  TEC  rs6837335G > A0.3533.12e-04C1.06 (1.03-1.09)C
4q13.3chr4:73859603-74142734CXCL1  CXCL5  PF4V1  PF4  CXCL6  CXCL8  CXCL3  CXCL2  rs2472649G > A0.1764.15e-07C1.1 (1.04-1.15)C
4q24chr4:102467408-103091883MANBA  NFKB1  rs3774959G > A0.3583.12e-03C1.04 (1.01-1.07)C
4q24chr4:101782996-102192580rs13126505G > A0.0961.19e-06C1.11 (1.05-1.17)C
4q27chr4:122017479-122644147IL21  IL2  rs7657746A > G0.2472.76e-13C1.11 (1.08-1.15)C
5p13.1chr5:40286865-40626651PTGER4  rs11742570C > T0.3953.46e-59C1.19 (1.16-1.23)C
5p15.2chr5:10667329-10833902DAP  rs2930047T > C0.3821.03e-08C1.07 (1.03-1.10)C
5p15.33chr5:490122-717906SLC9A3  rs11739663T > C0.2401.04e-03C1.02 (0.99-1.05)C
5q11.2chr5:56121772-56154384IL6ST  IL31RA  rs10065637C > T0.2276.25e-08C1.09 (1.05-1.12)C
5q13.2chr5:73161293-73284584rs7702331A > G0.3794.77e-06C1.05 (1.02-1.09)C
5q15chr5:96743698-97141497LNPEP  ERAP1  ERAP2  rs1363907G > A0.4118.71e-12C1.07 (1.04-1.10)C
5q23.3chr5:130189256-131985036rs4836519T > C0.2326.18e-07C1.08 (1.04-1.11)C
5q31.1chr5:132075186-132658977IL3  PDLIM4  IRF1  IL5  IL4  SLC22A5  CSF2  IL13  ACSL6  SLC22A4  rs2188962C > T0.4253.74e-37C1.16 (1.13-1.19)C
5q31.1chr5:135044841-135190861rs254560G > A0.3971.54e-08C1.04 (1.01-1.07)C
5q31.3chr5:142033064-142260854SPRY4  NDFIP1  rs6863411T > A0.3701.25e-12C1.09 (1.05-1.12)C
5q33.1chr5:150658703-151012930TNIP1  IRGM  rs11741861A > G0.0932.31e-26C1.25 (1.19-1.31)C
5q33.3chr5:159397971-159460964IL12B  rs6871626C > A0.3371.43e-42C1.18 (1.15-1.22)C
5q35.2chr5:173797287-174112331CPEB4  rs17695092T > G0.2975.14e-06C1.08 (1.04-1.11)C
5q35.3chr5:177079730-177421018DOK3  rs12654812G > A0.3351.68e-08C1.07 (1.04-1.10)C
6p22.3chr6:20639373-21029922rs9358372A > G0.3791.55e-12C1.09 (1.06-1.12)C
6p22.3chr6:21338901-21476386rs12663356C > T0.4672.54e-06C1.05 (1.02-1.09)C
6p23chr6:14691381-14736360rs17119A > G0.2143.08e-11C1.08 (1.03-1.11)C
6q15chr6:90097116-90319078rs1847472C > A0.3451.10e-09C1.06 (1.03-1.09)C
6q21chr6:105954686-106099497rs6568421A > G0.3012.52e-17C1.11 (1.07-1.14)C
6q21chr6:111075054-111647042TRAF3IP2  FYN  REV3L  rs3851228A > T0.0731.08e-13C1.15 (1.09-1.22)C
6q22.33chr6:126764254-127221808rs9491697A > G0.4391.14e-06C1.06 (1.03-1.09)C
6q22.33chr6:127629641-128019645rs13204742G > T0.1241.19e-08C1.13 (1.09-1.18)C
6q23.3chr6:137568592-137806067TNFAIP3  rs6920220G > A0.2061.01e-14C1.10 (1.06-1.14)C
6q24.2chr6:143504346-143711180PHACTR2  rs12199775A > G0.0711.99e-08C1.12 (1.06-1.19)C
6q25.3chr6:158903940-159121739TAGAP  rs212388T > C0.4101.89e-05C1.06 (1.03-1.09)C
6q27chr6:166931410-167134466RNASET2  RP11-517H2.6  RPS6KA2  CCR6  rs1819333T > G0.4773.63e-15C1.08 (1.05-1.11)C
7p12.2chr7:50206640-50325467IKZF1  ZPBP  rs1456896T > C0.3129.76e-14C1.09 (1.05-1.12)C
7p15.1chr7:28080094-28222707CREB5  JAZF1  rs864745C > T0.4973.09e-04C1.06 (1.03-1.09)C
7p15.2chr7:27157700-27280195rs4722672T > C0.1831.85e-05C1.04 (1.00-1.07)C
7p15.2chr7:26618343-27162670rs10486483G > A0.2471.50e-04C1.06 (1.02-1.09)C
7p22.3chr7:2695130-2891602GNA12  CARD11  TTYH3  rs798502A > C0.2911.23e-09C1.06 (1.03-1.1)C
7q22.1chr7:99119190-99271073SMURF1  rs9297145A > C0.2658.21e-12C1.08 (1.05-1.12)C
7q22.1chr7:100502511-100911543EPO  rs1734907G > A0.1491.92e-10C1.11 (1.07-1.16)C
7q31.1chr7:107820310-107964373DLD  rs4380874C > T0.4057.13e-17C1.07 (1.04-1.10)C
7q31.2chr7:117234417-117597881rs38904T > C0.4682.58e-07C1.05 (1.02-1.09)C
7q32.1chr7:128911686-129137466TSPAN33  IRF5  TNPO3  rs4728142G > A0.4441.48e-06C1.06 (1.03-1.09)C
8q21.3chr8:89628493-89942373RIPK2  rs7015630T > C0.2616.53e-06C1.05 (1.02-1.09)C
8q24.13chr8:125438839-125562774TRIB1  rs921720G > A0.3916.71e-15C1.08 (1.05-1.11)C
8q24.21chr8:128484980-128585383rs6651252T > C0.1351.29e-08C1.12 (1.08-1.16)C
8q24.21chr8:129468135-129685804rs1991866C > G0.4221.65e-09C1.05 (1.02-1.08)C
9p24.1chr9:4944089-5274545JAK2  rs10758669A > C0.3497.88e-45C1.17 (1.14-1.21)C
9q22.31chr9:91134438-91402091NFIL3  rs4743820T > C0.2986.45e-09C1.05 (1.02-1.09)C
9q32chr9:114715997-114937465TNFSF8  TNC  TNFSF15  rs4246905C > T0.2912.80e-32C1.14 (1.11-1.18)C
9q34.3chr9:136243135-136514725CARD9  INPP5E  SDCCAG3  PMPCA  rs10781499G > A0.4124.38e-56C1.19 (1.15-1.22)C
10p11.21chr10:34887225-35588558CREM  rs11010067C > G0.3466.72e-23C1.12 (1.08-1.15)C
10p11.23chr10:30398004-30522007MAP3K8  rs1042058C > T0.4082.10e-10C1.08 (1.04-1.11)C
10p15.1chr10:5987834-6098857IL2RA  IL15RA  rs12722515C > A0.1515.82e-09C1.1 (1.06-1.15)C
10q21.1chr10:58064134-58408714CISD1  IPMK  rs2790216G > A0.2221.60e-07C1.06 (1.03-1.1)C
10q21.2chr10:62581266-62866159rs10761659G > A0.4578.47e-45C1.16 (1.14-1.2)C
10q22.2chr10:73639542-73945471rs2227564C > T0.2306.65e-06C1.09 (1.05-1.12)C
10q22.3chr10:79237086-79312766rs1250546A > G0.3968.28e-15C1.1 (1.06-1.12)C
10q23.1chr10:80326790-80603584TSPAN14  FAM213A  rs6586030G > A0.1531.27e-14C1.11 (1.08-1.15)C
10q23.33chr10:92439580-92742146rs7911264C > T0.4812.98e-08C1.06 (1.03-1.1)C
10q24.2chr10:99508770-99570210NKX2-3  rs4409764G > T0.4911.03e-54C1.18 (1.15-1.22)C
11p15.5chr11:1845142-1946041LSP1  TNNI2  rs907611G > A0.3152.70e-10C1.07 (1.04-1.10)C
11q12.1chr11:58132360-58690335CNTF  LPXN  rs10896794T > C0.2386.80e-10C1.08 (1.04-1.11)C
11q12.2chr11:60962649-61068645PTGDR2  CD6  CD5  rs11230563C > T0.3469.03e-13C1.09 (1.05-1.12)C
11q12.2chr11:61749438-61917078MYRF  FADS1  FADS2  rs4246215G > T0.3381.49e-10C1.08 (1.05-1.11)C
11q13.1chr11:64081858-64457156TRPT1  RPS6KA4  FLRT1  CCDC88B  rs559928C > T0.1794.19e-11C1.1 (1.06-1.14)C
11q13.1chr11:65604133-66296655CTSW  RELA  FOSL1  SNX32  rs2231884C > T0.1572.96e-06C1.08 (1.04-1.12)C
11q13.5chr11:76324636-76632292rs2155219T > G0.4914.24e-36C1.15 (1.12-1.19)C
11q14.2chr11:87236723-87522249rs6592362G > A0.2482.32e-08C1.08 (1.05-1.12)C
11q21chr11:96246567-96484952JRKL  MAML2  rs483905G > A0.2921.03e-05C1.03 (1.00-1.06)C
11q23.2chr11:114386027-114704768NXPE1  NXPE4  rs561722C > T0.3374.61e-08C1.05 (1.02-1.09)C
11q23.3chr11:118606652-118952438CXCR5  rs630923C > A0.1542.63e-06C1.08 (1.04-1.11)C
12p13.2chr12:12384138-12579426BORCS5  rs11612508A > G0.2672.56e-06C1.06 (1.03-1.09)C
12q12chr12:40223113-40613085LRRK2  rs11564258G > A0.0255.04e-23C1.33 (1.22-1.46)C
12q13.11chr12:47788458-47837647VDR  rs11168249T > C0.4674.59e-08C1.05 (1.02-1.08)C
12q15chr12:68036752-68116292IL22  IL26  IFNG  rs7134599G > A0.3781.22e-22C1.10 (1.06-1.13)C
13q12.13chr13:26932960-26990142rs17085007T > C0.1833.75e-13C1.11 (1.07-1.15)C
13q14.11chr13:40435146-40471356rs941823C > T0.2423.84e-10C1.08 (1.03-1.11)C
13q14.11chr13:43662130-44029117LACC1  rs3764147A > G0.2485.63e-13C1.11 (1.07-1.15)C
13q32.3chr13:99110747-99432425GPR18  GPR183  rs9557195T > C0.2282.37e-14C1.11 (1.08-1.15)C
14q24.1chr14:68696738-68851345ZFP36L1  rs194749T > C0.2263.86e-08C1.08 (1.04-1.11)C
14q24.3chr14:75204956-75283172FOS  MLH3  rs4899554C > T0.1813.39e-06C1.09 (1.04-1.12)C
14q31.3chr14:87863352-88175959GALC  GPR65  rs8005161C > T0.0892.35e-14C1.15 (1.10-1.21)C
15q14chr15:38522176-38679976RASGRP1  SPRED1  rs16967103T > C0.2032.48e-05C1.07 (1.03-1.11)C
15q15.1chr15:40915941-41573290NDUFAF1  NUSAP1  ITPKA  rs28374715A > G0.2622.11e-05C1.04 (1.01-1.08)C
15q22.33chr15:67120258-67176997SMAD3  rs17293632C > T0.2355.92e-15C1.07 (1.03-1.10)C
15q26.1chr15:90382489-90725453CRTC3  rs7495132C > T0.1099.48e-11C1.14 (1.09-1.19)C
16p11.2chr16:28283985-29014657IL27  SULT1A1  EIF3C  NUPR1  RABEP2  SULT1A2  rs26528T > C0.4514.69e-18C1.10 (1.07-1.13)C
16p11.2chr16:30135944-30542838ITGAL  rs11150589C > T0.4631.87e-06C1.05 (1.02-1.08)C
16p12.2chr16:23720685-23964030PRKCB  rs7404095C > T0.4289.68e-10C1.06 (1.03-1.09)C
16p13.13chr16:11210761-11380893RMI2  SOCS1  LITAF  rs529866C > T0.1971.49e-12C1.12 (1.09-1.16)C
16q12.1chr16:50658453-50824433ADCY7  NOD2  rs2066847C > T0.0242.90e-69C1.30 (1.25-1.34)C
16q22.1chr16:68395991-68806685ZFP90  rs1728785C > A0.2334.43e-06C1.04 (1.0-1.08)C
16q24.1chr16:85949450-85990498IRF8  rs10521318C > T0.0851.41e-09C1.15 (1.1-1.22)C
17q11.2chr17:27286355-27690219LGALS9  LGALS9C  NOS2  rs2945412A > G0.4131.23e-05C1.08 (1.04-1.11)C
17q12chr17:39219977-40074859GSDMA  GSDMB  ZPBP2  ORMDL3  IKZF3  rs12946510C > T0.4654.10e-38C1.16 (1.12-1.19)C
17q12chr17:34175049-34352741CCL13  CCL11  CCL2  rs3091316G > A0.2785.26e-20C1.12 (1.09-1.16)C
17q21.2chr17:42156716-42774617STAT3  STAT5A  STAT5B  rs12942547A > G0.4205.51e-22C1.1 (1.08-1.14)C
17q23.1chr17:59412005-59997425RPS6KB1  TUBD1  rs1292053A > G0.4461.77e-10C1.08 (1.05-1.11)C
17q24.3chr17:72591636-72652289rs7210086A > C0.2039.58e-08C1.06 (1.02-1.1)C
18p11.21chr18:12738414-12925254rs1893217A > G0.1573.05e-26C1.17 (1.13-1.22)C
18q21.1chr18:48827214-48922435SMAD7  rs7240004A > G0.3849.81e-09C1.05 (1.02-1.09)C
18q22.2chr18:69831437-69902924CD226  rs727088A > G0.4844.65e-09C1.08 (1.05-1.11)C
19p13.2chr19:10292692-10520699ICAM1  TYK2  PPAN-P2RY11  rs11879191G > A0.2032.04e-18C1.14 (1.1-1.18)C
19p13.3chr19:1090804-1183852GPX4  HMHA1  rs2024092G > A0.2151.23e-15C1.10 (1.06-1.14)C
19q13.11chr19:33219244-33272215CEBPG  rs17694108G > A0.2825.85e-15C1.10 (1.07-1.14)C
19q13.32chr19:46546671-46648121CALM3  rs1126510A > G0.3631.59e-06C1.04 (1.01-1.07)C
19q13.32chr19:46304332-46410492rs4802307G > T0.2947.11e-07C1.06 (1.03-1.1)C
19q13.33chr19:48592641-48763133FUT2  DBP  SPHK2  IZUMO1  rs516246C > T0.4834.33e-09C1.07 (1.04-1.10)C
19q13.42chr19:54783517-54916142NLRP7  NLRP2  KIR2DL1  LILRB4  rs11672983G > A0.3922.48e-09C1.09 (1.06-1.12)C
20q11.21chr20:32611779-33001967DNMT3B  rs4911259T > G0.3831.20e-09C1.08 (1.04-1.11)C
20q11.21chr20:31995378-32517173HCK  rs6142618G > A0.4366.05e-10C1.08 (1.04-1.1)C
20q11.22chr20:34322913-35581362CEP250  PROCR  UQCC1  rs6088765T > G0.4379.85e-06C1.05 (1.02-1.09)C
20q13.12chr20:45906223-46158839MMP9  PLTP  CD40  rs1569723A > C0.2596.55e-11C1.09 (1.06-1.13)C
20q13.12chr20:44430797-44508282HNF4A  ADA  rs6017342C > A0.4701.43e-21C1.11 (1.09-1.15)C
20q13.13chr20:50301749-50423945CEBPB  rs913678T > C0.3384.59e-08C1.05 (1.02-1.09)C
20q13.32chr20:59153293-59295301ZNF831  CTSZ  rs259964G > A0.4641.01e-12C1.09 (1.05-1.12)C
20q13.33chr20:63567747-63814828TNFRSF6B  SLC2A4RG  LIME1  ZGPAT  rs6062504G > A0.3161.09e-23C1.1 (1.08-1.14)C
21q21.1chr21:15326120-15470979rs2823286G > A0.2929.28e-30C1.16 (1.12-1.19)C
21q22.2chr21:39081110-39111851rs2836878G > A0.2677.27e-43C1.18 (1.14-1.22)C
21q22.3chr21:44152485-44266077CH507-9B2.1  ICOSLG  rs7282490A > G0.3912.35e-26C1.11 (1.07-1.14)C
21q22.11chr21:33370311-33842379IFNGR2  IFNAR1  IFNAR2  IL10RB  GART  TMEM50B  rs2284553G > A0.4011.53e-08C1.08 (1.04-1.1)C
22q11.21chr22:21454896-21649639CCDC116  UBE2L3  MAPK1  YDJC  RIMBP3  rs2266959G > T0.1861.39e-16C1.11 (1.07-1.15)C
22q12.2chr22:29651931-30271212OSM  MTMR3  LIF  rs2412970A > G0.4572.70e-14C1.08 (1.05-1.11)C
22q13.1chr22:39253129-39364639APOBEC3G  ATF4  TAB1  rs2413583C > T0.1674.40e-33C1.2 (1.16-1.25)C
MHCchr6:32426760-32715138HLA-DQA1  HLA-DQB1  HLA-DQA2  HLA-DRB1  HLA-DRA  rs6927022A > G0.4653.19e-52C1.14 (1.1-1.18)C
MHCchr6:31253891-31375183NFKBIL1  PSORS1C1  MICB  HLA-C  rs9264942T > C0.3787.26e-14C1.08 (1.05-1.12)C

Criteria

GDXHsS00017 meets the following criteria:

Criteria Name
Details
Disease Tags
Study for a Disease 

Publications

PMIDTitleFirst AuthorJournalDisease(s)Date