Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Overview

Study Paper

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 2007-06-07

Study Type

Whole Genome Association Study

Samples

Group	Phenotype	Cases	Controls	Families	Trios
Discovery	BD	1868	-	-	-
Discovery	CAD	1926	-	-	-
Discovery	CRO	1748	-	-	-
Discovery	HT	1952	-	-	-
Discovery	NULL	-	2938	-	-
Discovery	RA	1860	-	-	-
Discovery	T1D	1963	-	-	-
Discovery	T2D	1924	-	-	-

Study Association

Region	Location	Marker	Allele	MAF	P Value	Odds Ratio
1p13.2	chr1:113288123-114002809	rs6679677	C > A	0.096	5.55e-25^D	1.98 (1.72-2.27)^D
1p13.2	chr1:113288123-114002809	rs6679677	C > A	0.096	5.55e-25^D	1.98 (1.72-2.27)^D
1p31.3	chr1:67128876-67302310	rs11805303	C > T	0.317	5.85e-12^D	1.39 (1.22-1.58)^D
1p36.32	chr1:2431888-2880054	rs6684865	G > A	0.338	3.14e-05^D	1.27 (1.02-1.56)^D
1q24.3	chr1:172742823-172975611	rs12037606	G > A	0.388	1.09e-05^D	1.22 (1.07-1.40)^D
1q42.12	chr1:225366293-225775963	rs2639703	T > C	0.276	1.74e-05^D	1.15 (1.02-1.30)^D
2q37.1	chr2:233232538-233670717	rs10210302	T > C	0.481	5.26e-14^D	1.19 (1.01-1.41)^D
3p21.31	chr3:48414698-50711580	rs9858542	G > A	0.282	3.58e-08^D	1.09 (0.96-1.24)^D
4p15.2	chr4:25109041-25455580	rs3816587	T > C	0.406	9.25e-06^D	1.1 (0.96-1.25)^D
4q27	chr4:122017479-122644147	rs6534347	G > A	0.351	1.83e-06^D	1.30 (1.10-1.55)^D
4q27	chr4:122041392-122644147	rs17388568	G > A	0.260	3.27e-06^D	1.26 (1.11-1.42)^D
5p13.1	chr5:40286865-40626651	rs17234657	T > G	0.125	1.99e-12^D	1.54 (1.34-1.76)^D
5q14.3	chr5:86836103-87169922	rs2544677	C > G	0.242	4.43e-05^D	1.33 (1.0-1.79)^D
5q31.1	chr5:132066493-132645156	rs6596075	C > G	0.166	3.19e-06^D	1.54 (1.0-2.38)^D
5q31.1	chr5:133276293-133329832	rs17166496	C > G	0.391	5.20e-06^D	1.30 (1.15-1.47)^D
5q33.1	chr5:150658703-151012930	rs1000113	c > T	0.067	3.15e-07^D	1.54 (1.31-1.82)^D
6p22.3	chr6:20522059-20919892	rs6908425	C > T	0.230	1.10e-05^D	1.64 (1.18-2.27)^D
6q23.3	chr6:137636199-137927704	rs7753394	T > C	0.482	2.59e-05^D	1.21 (1.04-1.40)^D
6q23.3	chr6:137568592-137806067	rs6920220	G > A	0.223	1.58e-05^D	1.20 (1.06-1.36)^D
7q32.3	chr7:131651764-131698797	rs11761231	G > A	0.375	1.37e-06^D	1.45 (1.19-1.75)^D
7q36.1	chr7:148487312-148564440	rs7807268	C > G	0.462	4.42e-06^D	1.38 (1.20-1.60)^D
10p15.1	chr10:5988280-6129961	rs2104286	T > C	0.286	4.32e-05^D	1.3 (1.02-1.64)^D
10p15.1	chr10:5988280-6129961	rs2104286	T > C	0.286	4.32e-05^D	1.3 (1.02-1.64)^D
10p15.1	chr10:3818510-3825864	rs6601764	T > C	0.408	8.95e-06^D	1.16 (1.01-1.33)^D
10q21.2	chr10:62581266-62866159	rs10761659	G > A	0.461	1.75e-06^D	1.23 (1.05-1.45)^D
10q24.2	chr10:99508770-99570210	rs10883365	A > G	0.477	5.82e-08^D	1.20 (1.03-1.39)^D
12p13.31	chr12:9347245-9815492	rs11052552	G > T	0.486	7.24e-07^D	1.49 (1.28-1.72)^D
12p13.31	chr12:9343806-9813007	rs3764021	G > T	0.467	5.08e-08^D	1.56 (1.39-1.79)^D
12q13.2	chr12:55958153-56398232	rs11171739	T > C	0.423	9.71e-11^D	1.34 (1.17-1.54)^D
12q24.13	chr12:111299311-112592683	rs17696736	A > G	0.424	1.51e-14^D	1.34 (1.16-1.53)^D
13q12.11	chr13:20347851-20386207	rs9550642	G > A	0.084	3.90e-05^D	1.34 (1.15-1.56)^D
16p13.13	chr16:10923201-11218316	rs12708716	A > G	0.350	4.92e-07^D	1.19 (0.97-1.45)^D
16q12.1	chr16:50655913-50822931	rs17221417	C > G	0.287	3.98e-11^D	1.29 (1.13-1.46)^D
18p11.21	chr18:12738414-12925254	rs2542151	T > G	0.163	1.16e-05^D	1.30 (1.15-1.47)^D
18p11.21	chr18:12738414-12925254	rs2542151	T > G	0.163	1.16e-05^D	1.30 (1.15-1.47)^D
19q13.32	chr19:45641767-45922818	rs8111071	A > G	0.070	1.75e-05^D	1.47 (1.25-1.73)^D
21q22.2	chr21:41122022-41174890	rs2837960	T > G	0.171	1.68e-06^D	1.05 (0.93-1.2)^D
22q12.3	chr22:37142468-37166071	rs743777	A > G	0.292	1.15e-06^D	1.09 (0.97-1.24)^D
MHC	chr6:32414162-32714887	rs9272346	A > G	0.387	5.47e-134^D	5.56 (4.76-6.25)^D
MHC	chr6:32480784-32727855	rs6457617	C > T	0.489	5.18e-75^D	2.36 (1.97-2.84)^D
MHC	chr6:32463928-32718134	rs9469220	G > A	0.481	2.28e-06^D	1.14 (0.98-1.32)^D

Criteria

GDXHsS00005 meets the following criteria:

Criteria Name

Details

Disease Tags

Study for a Disease

CRO RA T1D

Publications

PMID	Title	First Author	Journal	Disease(s)	Date