Overview

IDAllelesLocationGenome BuildSource
rs4819388T/Cchr21: 4422753838dbsnp146
rs4819388T/C chr21: 45647421 37dbsnp146_grch37
imm_21_44471849T/C chr21: 44227538 38ImmunoChip
imm_21_44471849T/C chr21: 45647421 37ImmunoChip
imm_21_44471849T/C chr21: 44471849 36ImmunoChip

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Historical Ids

Old Marker IDNew Marker IDCurrent Marker IDdbSNP Build
rs58240752rs4819388rs4819388130

Criteria

rs4819388 meets the following criteria:

Criteria Name
Details
Disease Tags
Marker is GW-Significant in a Study 
Marker is an index SNP in a Region 

Functional Information

Gene function properties for rs4819388 as derived from dbSNP:
  • in intron
  • in 3prime utr
Gene(s) at location of variation:  ICOSLG 

Study

Studies containing regions of association that span this marker are shown below. Please note that when making comparisons across studies, that they may vary in terms of size, genotyping platform, and exclusion criteria. If the 'Odds Ratio' is less than 1 then the region is protective (alleles are marked as blue) otherwise it is susceptible (alleles marked as red).

StudyPublicationDiseaseRegionMarkerAllelesP-valueORMAFGene(s)

Populations

Populations data from Ensembl 1000 Genome data release May 2013:

Linkage Disequilibrium Statistics

LD Search Options

Linkage disequilibrium (LD) statistics are calculated for rs4819388, using the 1000 genomes data release May 2013. Calculations are performed with the snpStats R library, covering 1Mb either side of the marker; and with the following filters applied: MAF > 0.01, call rate < 0.9, and chi-squared test for deviation from HWE > 25.