IDAllelesLocationGenome BuildSource
rs4819388T/Cchr21: 4422753838dbsnp146
rs4819388T/C chr21: 45647421 37dbsnp146_grch37
imm_21_44471849T/C chr21: 44227538 38ImmunoChip
imm_21_44471849T/C chr21: 45647421 37ImmunoChip
imm_21_44471849T/C chr21: 44471849 36ImmunoChip


Historical Ids

Old Marker IDNew Marker IDCurrent Marker IDdbSNP Build


rs4819388 meets the following criteria:

Criteria Name
Disease Tags
Marker is an index SNP in a Region 
Marker is GW-Significant in a Study 

Functional Information

Gene function properties for rs4819388 as derived from dbSNP:
  • in intron
  • in 3prime utr
Gene(s) at location of variation:  ICOSLG 


Studies containing regions of association that span this marker are shown below. Please note that when making comparisons across studies, that they may vary in terms of size, genotyping platform, and exclusion criteria. If the 'Odds Ratio' is less than 1 then the region is protective (alleles are marked as blue) otherwise it is susceptible (alleles marked as red).



Populations data from Ensembl 1000 Genome data release May 2013:

Linkage Disequilibrium Statistics

LD Search Options

Linkage disequilibrium (LD) statistics are calculated for rs4819388, using the 1000 genomes data release May 2013. Calculations are performed with the snpStats R library, covering 1Mb either side of the marker; and with the following filters applied: MAF > 0.01, call rate < 0.9, and chi-squared test for deviation from HWE > 25.