A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.
More details about the regions are available here.
|SSC 3p14.3||chr3:58099168-58563570||DNASE1L3 PXK||rs35677470 rs4681851|
|SSC 3q25.33||chr3:159883974-160033824||IL12A SCHIP1 IQCJ-SCHIP1||rs77583790|